Structure of PDB 3dl5 Chain A

Receptor sequence

>3dl5A (length=507) Species: 237895 (Cryptosporidium hominis)

EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNAL
IMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLM
NDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPE
TFLPVYMSQTFCTKNISYDFMIFEKQEKLKSIDDTVDLLGEIFGIRKMGN
RHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYS
IFGQMMRFDMRESFPLLTTKKVFIRSIFEELIWFIKGDTNGNHLIEKKVY
IWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVG
VDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDN
CLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAH
IYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPT
IKMDMAV

3D structure

• PDB: 3dl5 Explaining an unusually fast parasitic enzyme: folate tail-binding residues dictate substrate positioning and catalysis in Cryptosporidium hominis thymidylate synthase.
• Chain: A
• Resolution: 2.74 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	UMP	A	R257 C402 R423 S424 C425 D426 N434 Y466	R243 C388 R409 S410 C411 D412 N420 Y452
BS02	DHF	A	V10 A11 D32 L33 F36 S37 R70	V8 A9 D30 L31 F34 S35 R68
BS03	NDP	A	V10 A11 I19 G20 G23 Q24 L25 G55 R56 K57 T58 I75 S76 S77 G115 E116 S117 T145	V8 A9 I17 G18 G21 Q22 L23 G53 R54 K55 T56 I73 S74 S75 G113 E114 S115 T143
BS04	UMP	A	R382 R383	R368 R369

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Sat Nov 16 11:50:38 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '3dl5', asym_id = 'A', title = 'Explaining an unusually fast parasitic enzyme: f...in Cryptosporidium hominis thymidylate synthase. '

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='3dl5', asym_id='A', title='Explaining an unusually fast parasitic enzyme: f...in Cryptosporidium hominis thymidylate synthase. ')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0004146,0004799,0006231,0006730,0016741,0046654', uniprot = '', pdbid = '3dl5', asym_id = 'A'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0004146,0004799,0006231,0006730,0016741,0046654', uniprot='', pdbid='3dl5', asym_id='A')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>