Structure of PDB 3dkg Chain A

Receptor sequence
>3dkgA (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
TVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVICVYHGTLLDKKIHCA
VKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLP
YMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLASKKFVHRDLAAR
NCMLDEKFTVKVADFGLARLPVKWMALESLQTQKFTTKSDVWSFGVLLWE
LMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAE
MRPSFSELVSRISAIFSTFIGEHYVHVNATY
3D structure
PDB3dkg SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo.
ChainA
Resolution1.91 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1204 A1206 R1208 N1209 D1222
Catalytic site (residue number reindexed from 1) D146 A148 R150 N151 D164
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SX8 A I1084 A1108 L1157 Y1159 M1160 D1164 R1208 M1211 A1221 D1222 A1226 I35 A50 L99 Y101 M102 D106 R150 M153 A163 D164 A168 PDBbind-CN: -logKd/Ki=5.00,Ki<10uM
BindingDB: IC50=4.0nM,Kd=0.820000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3dkg, PDBe:3dkg, PDBj:3dkg
PDBsum3dkg
PubMed19934279
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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