Structure of PDB 3dk6 Chain A

Receptor sequence
>3dk6A (length=263) Species: 10090 (Mus musculus) [Search protein sequence]
DKWEMERTDITMKHKLGQFGEVYEGVWKKYSLTVAVKTLEVEEFLKEAAV
MKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVV
LLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMT
GDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSP
YPGIDPSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEI
HQAFETMFQESSI
3D structure
PDB3dk6 Crystal structure of mutant ABL kinase domain in complex with small molecule fragment
ChainA
Resolution2.02 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D363 A365 R367 N368 D381 P402
Catalytic site (residue number reindexed from 1) D124 A126 R128 N129 D142 P163
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SX7 A L248 V256 A269 T315 F317 M318 G321 N322 L370 F382 L16 V22 A35 T76 F78 M79 G82 N83 L131 F143
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3dk6, PDBe:3dk6, PDBj:3dk6
PDBsum3dk6
PubMed
UniProtP00520|ABL1_MOUSE Tyrosine-protein kinase ABL1 (Gene Name=Abl1)

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