Structure of PDB 3djo Chain A

Receptor sequence
>3djoA (length=124) Species: 9913 (Bos taurus) [Search protein sequence]
KESAAAKFERQHMDSGNSPSSSSNYCNLMMCCRKMTQGKCKPVNTFVHES
LADVKAVCSQKKVTCKNGQTNCYQSKSTMRITDCRETGSSKYPNCAYKTT
QVEKHIIVACGGKPSVPVHFDASV
3D structure
PDB3djo Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H12 K41 H119 F120 D121
Catalytic site (residue number reindexed from 1) H12 K41 H119 F120 D121
Enzyme Commision number 4.6.1.18: pancreatic ribonuclease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U2P A V43 N44 T45 K66 R85 F120 D121 V43 N44 T45 K66 R85 F120 D121 MOAD: Ki=40.8uM
PDBbind-CN: -logKd/Ki=4.39,Ki=40.8uM
BindingDB: Ki=40800nM
BS02 U2P A Q11 H12 Q11 H12 MOAD: Ki=40.8uM
PDBbind-CN: -logKd/Ki=4.39,Ki=40.8uM
BindingDB: Ki=40800nM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004519 endonuclease activity
GO:0004522 ribonuclease A activity
GO:0004540 RNA nuclease activity
GO:0016829 lyase activity
GO:0042802 identical protein binding
Biological Process
GO:0050830 defense response to Gram-positive bacterium
GO:0051607 defense response to virus
Cellular Component
GO:0005576 extracellular region

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3djo, PDBe:3djo, PDBj:3djo
PDBsum3djo
PubMed19643512
UniProtP00669|RNS_BOVIN Seminal ribonuclease (Gene Name=SRN)

[Back to BioLiP]