Structure of PDB 3dgz Chain A

Receptor sequence

>3dgzA (length=482) Species: 10090 (Mus musculus) [Search protein sequence]

QQSFDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTC
VNVGCIPKKLMHQAALLGGMIRDAHHYGWEVAQPVQHNWKTMAEAVQNHV
KSLNWGHRVQLQDRKVKYFNIKASFVDEHTVRGVDKGGKATLLSAEHIVI
ATGGRPRYPTQVKGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGF
LTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESHGTQFLKGCVPSHIKK
LPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGISTNP
KNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKS
STLMDYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEF
TVADRDASQCYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIKCGAS
YAQVMQTVGIHPTCSEEVVKLHISKRSGLEPT

3D structure

PDB

3dgz Crystal Structure of Mouse Mitochondrial Thioredoxin Reductase, C-terminal 3-residue truncation

Chain

Resolution

2.25 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	L49 C53 C58 K61 Y195 E199 G462 H464 E469
Catalytic site (residue number reindexed from 1)	L46 C50 C55 K58 Y192 E196 G459 H461 E466
Enzyme Commision number	1.8.1.9: thioredoxin-disulfide reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G13 S16 G17 A35 D36 Y37 G51 T52 C53 G57 C58 K61 A126 T155 G156 Y195 R285 G325 D326 E333 L334 T335	G10 S13 G14 A32 D33 Y34 G48 T49 C50 G54 C55 K58 A123 T152 G153 Y192 R282 G322 D323 E330 L331 T332
BS02	NA7	A	R160 A193 S194 R216 R221 I283 G284 R285	R157 A190 S191 R213 R218 I280 G281 R282

Gene Ontology

	Molecular Function
GO:0004791	thioredoxin-disulfide reductase (NADPH) activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0042803	protein homodimerization activity
GO:0050660	flavin adenine dinucleotide binding

	Biological Process
GO:0000305	response to oxygen radical
GO:0006979	response to oxidative stress
GO:0007507	heart development
GO:0030097	hemopoiesis
GO:0045454	cell redox homeostasis
GO:0098869	cellular oxidant detoxification

	Cellular Component
GO:0005739	mitochondrion

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:3dgz, PDBe:3dgz, PDBj:3dgz
PDBsum	3dgz
PubMed
UniProt	Q9JLT4\|TRXR2_MOUSE Thioredoxin reductase 2, mitochondrial (Gene Name=Txnrd2)

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