Structure of PDB 3dbe Chain A

Receptor sequence
>3dbeA (length=284) Species: 7955 (Danio rerio) [Search protein sequence]
KEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKS
MLLKPHQKEKMSTEIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEICRRRS
LLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDD
MDVKIGDFGLATKIEFDGERKKDLPNYIAPEVLCKKGHSFEVDIWSLGCI
LYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASALIRRMLHADP
TLRPSVAELLTDEFFTSGYAPMRLPTSCLTVPPR
3D structure
PDB3dbe Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
ChainA
Resolution3.32 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D162 K164 G166 N167 D180
Catalytic site (residue number reindexed from 1) D139 K141 G143 N144 D157
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4FR A L45 G46 K47 C53 A66 K68 E117 C119 R120 R122 F169 L22 G23 K24 C30 A43 K45 E94 C96 R97 R99 F146
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3dbe, PDBe:3dbe, PDBj:3dbe
PDBsum3dbe
PubMed18793847
UniProtQ4KMI8

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