Structure of PDB 3dbc Chain A

Receptor sequence
>3dbcA (length=261) Species: 7955 (Danio rerio) [Search protein sequence]
KEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKS
MLLKPHQKEKMSTEIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEICRRRS
LLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDD
MDVKIGDFGLATKIHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRI
KKNEYSVPRHINPVASALIRRMLHADPTLRPSVAELLTDEFFTSGYAPMR
LPTSCLTVPPR
3D structure
PDB3dbc Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
ChainA
Resolution3.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D162 K164 G166 N167 D180
Catalytic site (residue number reindexed from 1) D139 K141 G143 N144 D157
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2FR A L45 C53 L116 C119 R122 F169 L22 C30 L93 C96 R99 F146
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3dbc, PDBe:3dbc, PDBj:3dbc
PDBsum3dbc
PubMed18793847
UniProtQ4KMI8

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