Structure of PDB 3d94 Chain A

Receptor sequence
>3d94A (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
VYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTV
NEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRG
DLKSYLRSLRPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED
FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVW
SFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLLELMR
MCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEEN
3D structure
PDB3d94 Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1105 R1109 N1110 D1123 E1132
Catalytic site (residue number reindexed from 1) D139 R143 N144 D157 E166
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E1013 D1129 Y1131 E58 D163 Y165
BS02 D94 A L975 Q977 F980 V983 A1001 K1003 F1017 M1024 V1033 M1049 M1052 D1056 X1112 G1122 D1123 F1124 L20 Q22 F25 V28 A46 K48 F62 M69 V78 M94 M97 D101 X146 G156 D157 F158 MOAD: Ki=157nM
PDBbind-CN: -logKd/Ki=6.80,Ki=157nM
BindingDB: IC50=19nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:3d94, PDBe:3d94, PDBj:3d94
PDBsum3d94
PubMed18566589
UniProtP08069|IGF1R_HUMAN Insulin-like growth factor 1 receptor (Gene Name=IGF1R)

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