Structure of PDB 3d7v Chain A

Receptor sequence
>3d7vA (length=144) Species: 9606,10090 [Search protein sequence]
DDLYRQSLEIISRYLREQATGSKDGAAGRRALETLRRVGDGVQRNHETAF
QGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHL
KTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVE
3D structure
PDB3d7v A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
ChainA
Resolution2.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H224 G230 M231 K234 L235 S245 R248 V249 H252 V253 D256 N260 G262 R263 T266 F318 F319 H46 G52 M53 K56 L57 S67 R70 V71 H74 V75 D78 N82 G84 R85 T88 F140 F141
BS02 ZN A C286 E288 C108 E110
BS03 ZN A H320 E322 H142 E144
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:3d7v, PDBe:3d7v, PDBj:3d7v
PDBsum3d7v
PubMed18209102
UniProtP97287|MCL1_MOUSE Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Gene Name=Mcl1);
Q07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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