Structure of PDB 3d7t Chain A

Receptor sequence
>3d7tA (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
WALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEA
SVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLG
GDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGPVK
WTAPEALREAAFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK
GYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL
3D structure
PDB3d7t Structural basis for the recognition of c-Src by its inactivator Csk.
ChainA
Resolution2.899 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D314 A316 R318 N319 D332 P349
Catalytic site (residue number reindexed from 1) D127 A129 R131 N132 D145 P148
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU A I201 G202 V209 A220 K222 T266 M269 S273 R318 L321 S331 I14 G15 V22 A33 K35 T79 M82 S86 R131 L134 S144
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3d7t, PDBe:3d7t, PDBj:3d7t
PDBsum3d7t
PubMed18614016
UniProtP41240|CSK_HUMAN Tyrosine-protein kinase CSK (Gene Name=CSK)

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