Structure of PDB 3d5x Chain A

Receptor sequence
>3d5xA (length=279) Species: 7955 (Danio rerio) [Search protein sequence]
KEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKS
MLLKPHQKEKMSTEIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEICRRRS
LLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDD
MDVKIGDFGLATKIEFDGERKKDIAPEVLCKKGHSFEVDIWSLGCILYTL
LVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASALIRRMLHADPTLRP
SVAELLTDEFFTSGYAPMRLPTSCLTVPP
3D structure
PDB3d5x Structures of the wild-type and activated catalytic domains of Brachydanio rerio Polo-like kinase 1 (Plk1): changes in the active-site conformation and interactions with ligands.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D162 K164 G166 N167 D180
Catalytic site (residue number reindexed from 1) D139 K141 G143 N144 D157
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KWT A G48 A51 C53 K68 V100 C119 F169 G25 A28 C30 K45 V77 C96 F146
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3d5x, PDBe:3d5x, PDBj:3d5x
PDBsum3d5x
PubMed18703838
UniProtQ4KMI8

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