Structure of PDB 3d5w Chain A

Receptor sequence
>3d5wA (length=285) Species: 7955 (Danio rerio) [Search protein sequence]
KEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKS
MLPHQKEKMSTEIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLL
ELHKRRKAVTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDDMD
VKIGDFGLATKIEFDGERKKTLCGTPNYIAPEVLCKKGHSFEVDIWSLGC
ILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASALIRRMLHAD
PTLRPSVAELLTDEFFTSGYAPMRLPTSCLTVPPR
3D structure
PDB3d5w Structures of the wild-type and activated catalytic domains of Brachydanio rerio Polo-like kinase 1 (Plk1): changes in the active-site conformation and interactions with ligands.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D162 K164 G166 N167 D180 T200
Catalytic site (residue number reindexed from 1) D137 K139 G141 N142 D155 T175
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A K47 A66 K68 C119 F169 K24 A43 K45 C94 F144
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3d5w, PDBe:3d5w, PDBj:3d5w
PDBsum3d5w
PubMed18703838
UniProtQ4KMI8

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