Structure of PDB 3d45 Chain A

Receptor sequence
>3d45A (length=383) Species: 10090 (Mus musculus) [Search protein sequence]
GPMEIIRSNFKINLHKVYQAIEEADFFAIDGEFSGISDSGFDTPEERYQK
LKKHSMDFLLFQFGLCAFKYDHTDSKHVTKSFNFYVFPKPFSRSSPDVKF
VCQSSSIDFLASQGFDFNKVFCSGIPYLNQEEERQLREQFDEYTKEQEEL
NDAVGFSRVIHAIANSGKLVVGHNMLLDVMHTIHQFYCPLPADLNEFKEM
AICVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFDPPKVESAE
GFPSYDQLHEAGYDAYITGLCFISMANYLGSSARSKLIEPFFNKLFLMRV
MDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWID
DTSAFVSLSQPEQVQIAVNTSKYAESYRIQTYA
3D structure
PDB3d45 Structural basis of m(7)GpppG binding to poly(A)-specific ribonuclease.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.13.4: poly(A)-specific ribonuclease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7MG A K319 N333 W449 W468 D470 D471 K212 N226 W329 W348 D350 D351 PDBbind-CN: -logKd/Ki=5.68,Kd=2.1uM
BS02 GDP A H280 N281 L284 K319 S335 M418 R419 H173 N174 L177 K212 S228 M298 R299
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004535 poly(A)-specific ribonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006402 mRNA catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3d45, PDBe:3d45, PDBj:3d45
PDBsum3d45
PubMed19217398
UniProtQ8VDG3|PARN_MOUSE Poly(A)-specific ribonuclease PARN (Gene Name=Parn)

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