Structure of PDB 3d44 Chain A

Receptor sequence
>3d44A (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
NTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDL
DIPGHASKDRYKDILPNPQSRVCLGRAQDGDYINANYIRGYDGKEKVYIA
TQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRCVHYWPTEEETYGPFQIRI
QDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVA
EVEESPETAAHPGPIVVHSSAGIGRTGCFIATRIGCQQLKARGEVDILGI
VCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPE
3D structure
PDB3d44 Structural basis of substrate recognition by hematopoietic tyrosine phosphatase.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D236 S270 R276 T277 Q314
Catalytic site (residue number reindexed from 1) D185 S219 R225 T226 Q263
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y104 D106 H237 S270 S271 A272 I274 G275 R276 Q314 Y61 D63 H186 S219 S220 A221 I223 G224 R225 Q263
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3d44, PDBe:3d44, PDBj:3d44
PDBsum3d44
PubMed19053285
UniProtP35236|PTN7_HUMAN Tyrosine-protein phosphatase non-receptor type 7 (Gene Name=PTPN7)

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