Structure of PDB 3d3p Chain A

Receptor sequence
>3d3pA (length=336) Species: 9606 (Homo sapiens) [Search protein sequence]
SISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQ
ERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLS
TPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDES
VLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHM
SLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLE
LYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIV
HPLWETWADLVQPDAQDILDTLEDNRNWYQAMIPQA
3D structure
PDB3d3p Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H238 H274 D275 D392 H87 H123 D124 D241
BS02 20A A M347 L393 N395 T407 I410 F414 M431 Q443 F446 M196 L242 N244 T256 I259 F263 M280 Q292 F295 MOAD: ic50=3.1nM
PDBbind-CN: -logKd/Ki=8.50,IC50=3.16nM
BindingDB: IC50=3.16nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:3d3p, PDBe:3d3p, PDBj:3d3p
PDBsum3d3p
PubMed18539455
UniProtQ07343|PDE4B_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4B (Gene Name=PDE4B)

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