Structure of PDB 3d23 Chain A

Receptor sequence
>3d23A (length=299) Species: 443239 (Human coronavirus HKU1 (isolate N1)) [Search protein sequence]
ASSGIVKMVSPTSKIEPCIVSVTYGSMTLNGLWLDDKVYCPRHVICSMNE
PDYSALLCRVTLGDFTIMSGRMSLTVVSYQMQGCQLVLTVSLQNPYTPKY
TFGNVKPGETFTVLAAYNGRPQGAFHVTMRSSYTIKGSFLCGSCGSVGYV
LTGDSVKFVYMHQLELSTGCHTGTDFTGNFYGPYRDAQVVQLPVKDYVQT
VNVIAWLYAAILNNCAWFVQNDVCSTEDFNVWAMANGFSQVKADLVLDAL
ASMTGVSIETLLAAIKRLYMGFQGRQILGSCTFEDELAPSDVYQQLAGV
3D structure
PDB3d23 Structure of the main protease from a global infectious human coronavirus, HCoV-HKU1.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H41 G143 C145
Catalytic site (residue number reindexed from 1) H43 G142 C144
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H41 F140 C145 H163 Q164 L165 E166 H172 Q189 V190 V191 H43 F139 C144 H162 Q163 L164 E165 H171 Q188 V189 V190
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3d23, PDBe:3d23, PDBj:3d23
PDBsum3d23
PubMed18562531
UniProtP0C6U3|R1A_CVHN1 Replicase polyprotein 1a (Gene Name=1a)

[Back to BioLiP]