Structure of PDB 3d15 Chain A

Receptor sequence
>3d15A (length=256) Species: 10090 (Mus musculus) [Search protein sequence]
RQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVE
HQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKL
SRFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADF
GWSVHAPSGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAH
TYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNASQRLTLAEVLEHPW
IKANSS
3D structure
PDB3d15 Discovery of a potent and selective aurora kinase inhibitor.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D269 K271 E273 N274 D287 T305
Catalytic site (residue number reindexed from 1) D131 K133 E135 N136 D149 T160
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AK2 A V160 K175 L177 V187 L191 E194 L223 A226 L276 D287 V22 K37 L39 V49 L53 E56 L85 A88 L138 D149 BindingDB: IC50=9nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:3d15, PDBe:3d15, PDBj:3d15
PDBsum3d15
PubMed18678489
UniProtP97477|AURKA_MOUSE Aurora kinase A (Gene Name=Aurka)

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