Structure of PDB 3d14 Chain A

Receptor sequence
>3d14A (length=262) Species: 10090 (Mus musculus) [Search protein sequence]
GPLGSRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLE
KAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYR
ELQKLSRFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGEL
KIADFGWSVHAPSCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGM
PPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNASQRLTLAE
VLEHPWIKANSS
3D structure
PDB3d14 Discovery of a potent and selective aurora kinase inhibitor.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D269 K271 E273 N274 D287 T305
Catalytic site (residue number reindexed from 1) D136 K138 E140 N141 D154 T166
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AK1 A F157 V160 K175 V187 Q190 L191 E194 L223 A226 L276 D287 F24 V27 K42 V54 Q57 L58 E61 L90 A93 L143 D154 MOAD: ic50=22nM
PDBbind-CN: -logKd/Ki=7.66,IC50=22nM
BindingDB: IC50=22nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3d14, PDBe:3d14, PDBj:3d14
PDBsum3d14
PubMed18678489
UniProtP97477|AURKA_MOUSE Aurora kinase A (Gene Name=Aurka)

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