Structure of PDB 3cye Chain A

Receptor sequence
>3cyeA (length=385) Species: 88776 (Influenza A virus (A/Brevig Mission/1/1918(H1N1))) [Search protein sequence]
VILTGNSSLCPISGWAIYSKDNGIRIGSKGDVFVIREPFISCSHLECRTF
FLTQGALLNDKHSNGTVKDRSPYRTLMSCPVGEAPSPYNSRFESVAWSAS
ACHDGMGWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECA
CVNGSCFTIMTDGPSNGQASYKILKIEKGKVTKSIELNAPNYHYEECSCY
PDTGKVMCVCRDNWHGSNRPWVSFDQNLDYQIGYICSGVFGDNPRPNDGT
GSCGPVSSNGANGIKGFSFRYDNGVWIGRTKSTSSRSGFEMIWDPNGWTE
TDSSFSVRQDIVAITDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGQPK
ENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFSI
3D structure
PDB3cye Structure determination of the 1918 H1N1 neuraminidase from a crystal with lattice-translocation defects
ChainA
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 E277 R292 R371 Y406
Catalytic site (residue number reindexed from 1) D69 E196 R211 R286 Y320
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D293 G297 D324 G345 N347 D212 G216 D242 G260 N262
BS02 CA A D379 N381 D387 S389 D294 N296 D302 S304
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3cye, PDBe:3cye, PDBj:3cye
PDBsum3cye
PubMed18645233
UniProtQ9IGQ6|NRAM_I18A0 Neuraminidase (Gene Name=NA)

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