Structure of PDB 3cxl Chain A

Receptor sequence
>3cxlA (length=402) Species: 9606 (Homo sapiens) [Search protein sequence]
GVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAADQLL
IVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESI
HDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLMPVLKETEKIHN
FKVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKP
DLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSG
FSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITY
DAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLH
EKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDI
LF
3D structure
PDB3cxl Crystal structure of human chimerin 1 (CHN1).
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H206 C236 C239 C255 H149 C179 C182 C198
BS02 ZN A C219 C222 H244 C247 C162 C165 H187 C190
Gene Ontology
Molecular Function
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0008045 motor neuron axon guidance
GO:0043547 positive regulation of GTPase activity
GO:0048013 ephrin receptor signaling pathway
GO:0050770 regulation of axonogenesis
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3cxl, PDBe:3cxl, PDBj:3cxl
PDBsum3cxl
PubMed
UniProtP15882|CHIN_HUMAN N-chimaerin (Gene Name=CHN1)

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