Structure of PDB 3cwd Chain A

Receptor sequence
>3cwdA (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
SADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMM
GEDSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKY
GVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEF
AVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQ
LKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQ
EIYKDLY
3D structure
PDB3cwd Molecular recognition of nitrated fatty acids by PPAR gamma.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Q294 K301 V315 L468 E471 K474 Q74 K81 V95 L248 E251 K254
BS02 LNA A C285 Q286 S289 H449 Y473 C65 Q66 S69 H229 Y253
BS03 LNB A C285 Q286 S289 I341 H449 C65 Q66 S69 I121 H229 BindingDB: IC50=410nM,EC50=45nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3cwd, PDBe:3cwd, PDBj:3cwd
PDBsum3cwd
PubMed18604218
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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