Structure of PDB 3cvv Chain A

Receptor sequence

>3cvvA (length=519) Species: 7227 (Drosophila melanogaster) [Search protein sequence]

EKGASTSLYKKAGLMDSQRSTLVHWFRKGLRLHDNPALSHIFTAANAAPG
RYFVRPIFILDPGILDWMQVGANRWRFLQQTLEDLDNQLRKLNSRLFVVR
GKPAEVFPRIFKSWRVEMLTFETDIEPYSVTRDAAVQKLAKAEGVRVETH
CSHTIYNPELVIAKNLGKAPITYQKFLGIVEQLKVPKVLGVPEKLKNMPT
PPKDEVEQKDSAAYDCPTMKQLVKRPEELGPNKFPGGETEALRRMEESLK
DEIWVARFEKPNTAPNSLEPSTTVLSPYLKFGCLSARLFNQKLKEIIKRQ
PKHSQPPVSLIGQLMWREFYYTVAAAEPNFDRMLGNVYCMQIPWQEHPDH
LEAWTHGRTGYPFIDAIMRQLRQEGWIHHLARHAVACFLTRGDLWISWEE
GQRVFEQLLLDQDWALNAGNWMWLSASAFFHQYFRVYSPVAFGKKTDPQG
HYIRKYVPELSKYPAGCIYEPWKASLVDQRAYGCVLGTDYPHRIVKHEVV
HKENIKRMGAAYKVNREVR

3D structure

PDB

3cvv The archaeal cofactor F0 is a light-harvesting antenna chromophore in eukaryotes.

Chain

Resolution

2.1 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	Q299 W302 W330 H365 W384 W407
Catalytic site (residue number reindexed from 1)	Q313 W316 W344 H379 W398 W421
Enzyme Commision number	?

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	K246 P247 P293 Q299 W302 H365 L366 H369 W409 Q418 R421 Y423 S424 F428 K431	K260 P261 P307 Q313 W316 H379 L380 H383 W423 Q432 R435 Y437 S438 F442 K445	PDBbind-CN: Kd=8.6uM
BS02	dna	A	I157 H417 Y419 F420 R502 R505	I171 H431 Y433 F434 R516 R519	PDBbind-CN: Kd=8.6uM
BS03	FAD	A	K246 T258 T259 V260 L261 S262 L265 Q299 R303 Y306 W362 H365 R368 F391 D397 Q398 D399 L402 N403 N406 W407	K260 T272 T273 V274 L275 S276 L279 Q313 R317 Y320 W376 H379 R382 F405 D411 Q412 D413 L416 N417 N420 W421
BS04	FO1	A	R13 F44 I45 L46 D47 I50 M54 V56 R60 L64 D110 E112 Y114 S115 R118 K266 F267	R27 F58 I59 L60 D61 I64 M68 V70 R74 L78 D124 E126 Y128 S129 R132 K280 F281

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003904	deoxyribodipyrimidine photo-lyase activity
GO:0071949	FAD binding

	Biological Process
GO:0032922	circadian regulation of gene expression
GO:0043153	entrainment of circadian clock by photoperiod

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:3cvv, PDBe:3cvv, PDBj:3cvv
PDBsum	3cvv
PubMed	19570997
UniProt	Q8SXK5

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