Structure of PDB 3cvu Chain A

Receptor sequence

>3cvuA (length=501) Species: 7227 (Drosophila melanogaster)

RSTLVHWFRKGLRLHDNPALSHIFTAANAAPGRYFVRPIFILDPGILDWM
QVGANRWRFLQQTLEDLDNQLRKLNSRLFVVRGKPAEVFPRIFKSWRVEM
LTFETDIEPYSVTRDAAVQKLAKAEGVRVETHCSHTIYNPELVIAKNLGK
APITYQKFLGIVEQLKVPKVLGVPEKLKNMPTPPKDEVEQKDSAAYDCPT
MKQLVKRPEELGPNKFPGGETEALRRMEESLKDEIWVARFEKPNTAPNSL
EPSTTVLSPYLKFGCLSARLFNQKLKEIIKRQPKHSQPPVSLIGQLMWRE
FYYTVAAAEPNFDRMLGNVYCMQIPWQEHPDHLEAWTHGRTGYPFIDAIM
RQLRQEGWIHHLARHAVACFLTRGDLWISWEEGQRVFEQLLLDQDWALNA
GNWMWLSASAFFHQYFRVYSPVAFGKKTDPQGHYIRKYVPELSKYPAGCI
YEPWKASLVDQRAYGCVLGTDYPHRIVKHEVVHKENIKRMGAAYKVNREV
R

3D structure

• PDB: 3cvu Crystal structure and mechanism of a DNA (6-4) photolyase.
• Chain: A
• Resolution: 2.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Q299 W302 W330 H365 W384 W407
• Catalytic site (residue number reindexed from 1): Q295 W298 W326 H361 W380 W403

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	K246 P247 P293 Q299 W302 H365 L366 H369 W409 Q418 R421 V422 Y423 S424 F428 K431	K242 P243 P289 Q295 W298 H361 L362 H365 W405 Q414 R417 V418 Y419 S420 F424 K427
BS02	dna	A	I157 K161 H417 F420 R502	I153 K157 H413 F416 R498
BS03	FAD	A	K246 T258 T259 V260 L261 S262 L265 Q299 R303 Y306 H365 R368 F391 D397 Q398 D399 L402 N403 N406 W407	K242 T254 T255 V256 L257 S258 L261 Q295 R299 Y302 H361 R364 F387 D393 Q394 D395 L398 N399 N402 W403

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003677 DNA binding
• GO:0003904 deoxyribodipyrimidine photo-lyase activity
• GO:0071949 FAD binding

Biological Process

• GO:0032922 circadian regulation of gene expression
• GO:0043153 entrainment of circadian clock by photoperiod

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm

External links

• PDB: RCSB:3cvu, PDBe:3cvu, PDBj:3cvu
• PDBsum: 3cvu
• PubMed: 18956392
• UniProt: Q8SXK5