Structure of PDB 3ctt Chain A

Receptor sequence
>3cttA (length=862) Species: 9606 (Homo sapiens) [Search protein sequence]
VNELERINCIPDQPPTKATCDQRGCCWNPQGAVSVPWCYYSKNHSYHVEG
NLVNTNAGFTARLKNLPSSPVFGSNVDNVLLTAEYQTSNRFHFKLTDQTN
NRFEVPHEHVQSFSGNAAASLTYQVEISRQPFSIKVTRRSNNRVLFDSSI
GPLLFADQFLQLSTRLPSTNVYGLGEHVHQQYRHDMNWKTWPIFNRDTTP
NGNGTNLYGAQTFFLCLEDASGLSFGVFLMNSNAMEVVLQPAPAITYRTI
GGILDFYVFLGNTPEQVVQEYLELIGRPALPSYWALGFHLSRYEYGTLDN
MREVVERNRAAQLPYDVQHADIDYMDERRDFTYDSVDFKGFPEFVNELHN
NGQKLVIIVDPAISNNSSSSKPYGPYDRGSDMKIWVNSSDGVTPLIGEVW
PGQTVFPDYTNPNCAVWWTKEFELFHNQVEFDGIWIDMNEVSNFVDGSVS
GCSTNNLNNPPFTPRILDGYLFCKTLCMDAVQHWGKQYDIHNLYGYSMAV
ATAEAAKTVFPNKRSFILTRSTFAGSGKFAAHWLGDNTATWDDLRWSIPG
VLEFNLFGIPMVGPDICGFALDTPEELCRRWMQLGAFYPFSRNHNGQGYK
DQDPASFGADSLLLNSSRHYLNIRYTLLPYLYTLFFRAHSRGDTVARPLL
HEFYEDNSTWDVHQQFLWGPGLLITPVLDEGAEKVMAYVPDAVWYDYETG
SQVRWRKQKVEMELPGDKIGLHLRGGYIFPTQQPNTTTLASRKNPLGLII
ALDENKEAKGELFWDDGETKDTVANKVYLLCEFSVTQNRLEVNISQSTYK
DPNNLAFNEIKILGTEEPSNVTVKHNGVPSSPTVTYDSNLKVAIITDIDL
LLGEAYTVEWAH
3D structure
PDB3ctt Total syntheses of casuarine and its 6-O-alpha-glucoside: complementary inhibition towards glycoside hydrolases of the GH31 and GH37 families
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.20: alpha-glucosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3CU A Y299 D327 W441 D443 R526 D542 F575 H600 Y293 D321 W435 D437 R520 D536 F569 H594 MOAD: Ki=0.45uM
PDBbind-CN: -logKd/Ki=6.35,Ki=0.45uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3ctt, PDBe:3ctt, PDBj:3ctt
PDBsum3ctt
PubMed19123216
UniProtO43451|MGA_HUMAN Maltase-glucoamylase (Gene Name=MGAM)

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