Structure of PDB 3csl Chain A

Receptor sequence

>3cslA (length=753) Species: 615 (Serratia marcescens)

NDWVYDEPRSVSVISREQMDNRPARHAADILEQTTGAYSSVSQQDPALSV
NIRGIQDYGRVNMNIDGMRQNFQKSGHGQRNGTMYIDSELLSGVTIDKGT
TGGMGSAGTLGGIATFNTVSASDFLAPGKELGGKLHASTGDNGTHFIGSG
ILALGNETGDILLAASERHLGDYWPGNKGDIGNIRINNDTGNYDRYAESI
KNNKIPDTHYRMHSRLAKVGWNLPANQRLQLSYLQTQTASPIAGTLTNLG
TRPPYELGWKRTGYTDVMARNAAFDYSLAPEDVDWLDFQAKLYYVDTQDD
SDTYSTSSLLDNGYATRTRLRTYGAQAQNTSRFSLAPGHDFRANYGLEFY
YDKATSDSSRQGMEGVTPAGNRSVASLFANLTYDYDGWLTLEGGLRYDRY
RLRGQTGLSYPDLAKDGQRYTIDNPCKALRLTGCSTTTREDWDVDRDQGK
LSPTLAVAVRPGVEWLELYTTYGKSWRPPAITETLTNGSAHSSSTQYPNP
FLQPERSRAWEVGFNVQQPDLWFEGDRLVAKVAYFDTKVDNYINLAIDRN
KPGLVQPSIGNAAYVNNLSKTRFRGLEYQLNYDAGVFYADLTYTHMIGKN
EFCSNKAWLGGRLRYGDGSRRGNFYVEPDAASNDFVTCDGGTQFGSAAYL
PGDRGSVTLGGRAFDRKLDAGVTVRFAPGYQDSSVPSNYPYLADWPKYTL
FDLYASYKLTDSLTLRGSVENLTNRAYVVSYGETLANTLGRGRTVQGGVE
YRF

3D structure

• PDB: 3csl Heme uptake across the outer membrane as revealed by crystal structures of the receptor-hemophore complex.
• Chain: A
• Resolution: 2.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEM	A	G188 H189 T357 T359 T374 A602 H603 S606 Q608	G76 H77 T245 T247 T262 A490 H491 S494 Q496

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0015232 heme transmembrane transporter activity
• GO:0015344 siderophore uptake transmembrane transporter activity
• GO:0022857 transmembrane transporter activity
• GO:0046872 metal ion binding

Biological Process

• GO:0015886 heme transport
• GO:0033214 siderophore-dependent iron import into cell
• GO:0044718 siderophore transmembrane transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0009279 cell outer membrane
• GO:0019867 outer membrane

External links

• PDB: RCSB:3csl, PDBe:3csl, PDBj:3csl
• PDBsum: 3csl
• PubMed: 19144921
• UniProt: Q79AD2