Structure of PDB 3csk Chain A

Receptor sequence
>3cskA (length=710) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
SHFFADHDAPLSMLSVKTEYFPQLTDKEQKYAHFMSKASHAGSRVVMRQV
SHESEPIFDLILAIHSKLNGKYPEDDITQKQQTGLYLEYVSQFLSNLGNF
KSFGDTKFIPRCEVKFFKQLLELAKINPSSSPLTLSPVDVNHEFTSHHLF
STINELIDIGIYHVEEKAALLGFPSQGYTSAYYLGLPVTPEDMALLKEQL
FAELAILPENTRINKVGENSFQIWVASENVKNQITETYPSGQITLSNAVT
KVEFIFGDHSREMRLVASYLKEAQKFAANDTQKAMLQEYINHFVTGSSQA
HKEAQKLWVKDISPVIETNIGFIETYREPSGIIGEFESLVAIQNKERTAK
FSSLVNNAEEFISLLPWSKDYEKPIFNPPDFTSLEVLTFTGSGIPAGINI
PNYDDVRLKIGFKNVSLGNILSAAAKSSSKHPPSFISQEDRPIFEKYQSD
SFEVQVDIHELLGHGSGKLLTEFTDGFNFDKENPPLGLDGKPVSTYYKVG
ETWGSKFGQLAGPFEECRAEVIAMFLLTNKKILDIFGFHDVESQDKVIYA
GYLQMARAGLLALEYWNPKTGKWGQPHMQARFSIMKTFMKHSTDKNFLKL
EMNSTNDDFAIKLDKSLIKTAGHECVKDYLKHLHVYKCSGDVEQGSKYFI
DRSTVTPDLASLRDIVLSKRLPRRQFIQSNSYIDDNNKVTLKEYDETPQG
MLQSFLDREL
3D structure
PDB3csk The first structure of dipeptidyl-peptidase III provides insight into the catalytic mechanism and mode of substrate binding.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.14.4: dipeptidyl-peptidase III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H460 H465 E517 H459 H464 E516
BS02 MG A S364 L366 W368 S363 L365 W367
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3csk, PDBe:3csk, PDBj:3csk
PDBsum3csk
PubMed18550518
UniProtQ08225|DPP3_YEAST Probable dipeptidyl peptidase 3 (Gene Name=YOL057W)

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