Structure of PDB 3csd Chain A

Receptor sequence

>3csdA (length=256) Species: 100226 (Streptomyces coelicolor A3(2)) [Search protein sequence]

SEVALVTGATSGIGLEIARRLGKEGLRVFVCARGEEGLRTTLKELREAGV
EADGRTCDVRSVPEIEALVAAVVERYGPVDVLVNNAGRLGGGATAELADE
LWLDVVETNLTGVFRVTKQVLKAGGMLERGTGRIVNIASTGGKQGVVHAA
PYSASKHGVVGFTKALGLELARTGITVNAVCPGFVETPMAASVREHYSDI
WEVSTEEAFDRITARVPIGRYVQPSEVAEMVAYLIGPGAAAVTAQALNVC
GGLGNY

3D structure

PDB

3csd Actinorhodin Polyketide Ketoreductase Mutant P94L bound to NADPH and the Inhibitor Emodin

Chain

Resolution

2.29 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	G17 N114 S144 Y157 K161 Y202
Catalytic site (residue number reindexed from 1)	G12 N109 S139 Y152 K156 Y197
Enzyme Commision number	1.3.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	NDP	A	G13 T15 S16 G17 I18 A37 R38 G39 D63 V64 N90 A91 S144 Y157 K161 P187 G188 V190 T192 M194	G8 T10 S11 G12 I13 A32 R33 G34 D58 V59 N85 A86 S139 Y152 K156 P182 G183 V185 T187 M189
BS02	EMO	A	S144 Y157 G188 F189 V198	S139 Y152 G183 F184 V193
BS03	EMO	A	T145 Q149 V151	T140 Q144 V146

Gene Ontology

	Molecular Function
GO:0016491	oxidoreductase activity

	Biological Process
GO:0008202	steroid metabolic process
GO:0017000	antibiotic biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:3csd, PDBe:3csd, PDBj:3csd
PDBsum	3csd
PubMed
UniProt	P16544\|ACT3_STRCO Putative ketoacyl reductase (Gene Name=actIII)

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