Structure of PDB 3csc Chain A

Receptor sequence
>3cscA (length=429) Species: 9031 (Gallus gallus) [Search protein sequence]
ASSTNLKDVLAALIPKEQARIKTFRQQHGGTALGQITVDMSYGGMRGMKG
LVYETSVLDPDEGIRFRGFSIPECQKLLPKGGGGEPLPEGLFWLLVTGQI
PTGAQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAITALNSE
SNFARAYAEGILRTKYWEMVYESAMDLIAKLPCVAAKIYRNLYRAGSSIG
AIDSKLDWSHNFTNMLGYTDAQFTELMRLYLTIHSDHEGGNVSAHTSHLV
GSALSDPYLSFAAAMNGLAGPLHGLANQEVLGWLAQLQKAAGADASLRDY
IWNTLNSGRVVPGYGHAVLRKTDPRYTCQREFALKHLPGDPMFKLVAQLY
KIVPNVLLEQGAAANPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRALG
VLAQLIWSRALGFPLERPKSMSTDGLIAL
3D structure
PDB3csc 1.9-A structures of ternary complexes of citrate synthase with D- and L-malate: mechanistic implications.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S244 H274 H320 R329 D375
Catalytic site (residue number reindexed from 1) S243 H273 H316 R325 D371
Enzyme Commision number 2.3.3.1: citrate (Si)-synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO A R46 L273 H274 V314 V315 G317 Y318 G319 H320 A321 A366 A367 A368 N373 D375 R46 L272 H273 V310 V311 G313 Y314 G315 H316 A317 A362 A363 A364 N369 D371
BS02 LMR A H238 N242 H274 H320 R329 R401 H237 N241 H273 H316 R325 R397
Gene Ontology
Molecular Function
GO:0004108 citrate (Si)-synthase activity
GO:0016740 transferase activity
GO:0036440 citrate synthase activity
GO:0042802 identical protein binding
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0006101 citrate metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Biological Process
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Cellular Component
External links
PDB RCSB:3csc, PDBe:3csc, PDBj:3csc
PDBsum3csc
PubMed2043640
UniProtP23007|CISY_CHICK Citrate synthase, mitochondrial (Gene Name=CS)

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