Structure of PDB 3cs8 Chain A

Receptor sequence
>3cs8A (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
RGGSPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYD
MNSLMMGEDKIPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFV
NLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLR
KPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIE
DIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK
KTETDMSLHPLLQEIYKDL
3D structure
PDB3cs8 Structural and biochemical basis for the binding selectivity of peroxisome proliferator-activated receptor gamma to PGC-1alpha.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K301 L311 N312 Q314 V315 L318 L468 E471 K94 L104 N105 Q107 V108 L111 L261 E264
BS02 BRL A G284 C285 S289 L330 I341 M364 K367 H449 L453 L469 Y473 G77 C78 S82 L123 I134 M157 K160 H242 L246 L262 Y266 BindingDB: EC50=40nM,IC50=1.000000nM,Ki=8nM,Kd=0.145000nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:3cs8, PDBe:3cs8, PDBj:3cs8
PDBsum3cs8
PubMed18469005
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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