Structure of PDB 3cps Chain A

Receptor sequence
>3cpsA (length=334) Species: 353152 (Cryptosporidium parvum Iowa II) [Search protein sequence]
GTLGINGFGRIGRLVLRACMERNDITVVAINDPFMDVEYMAYLLKYDSVH
GNFNGTVEVSGDLCINGKVVKVFQAKDPAEIPWGASGAQIVCESTGVFTT
EEKASLHLKGGAKKVIISAPPKDNVPMYVMGVNNTEYDPSKFNVISNASC
TTNCLAPLAKIINDKFGIVEGLMTTVHSLTANQLTVDGPSKGDWRAGRCA
GNNIIPASTGAAKAVGKVIPALNGKLTGMAIRVPTPDVSVVDLTCKLAKP
ASIEEIYQAVKEASNGPMKGIMGYTSDDVVSTDFIGCKYSSIFDKNACIA
LNDSFVKLISWYDNESGYSNRLVDLAVYVASRGL
3D structure
PDB3cps Crystal structure of Cryptosporidium parvum glyceraldehyde-3-phosphate dehydrogenase.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C168 H195
Catalytic site (residue number reindexed from 1) C150 H177
Enzyme Commision number 1.2.1.12: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A N23 G24 G26 R27 I28 N48 D49 P50 F51 S112 T113 G114 F116 S136 C168 A199 N334 Y338 N6 G7 G9 R10 I11 N31 D32 P33 F34 S94 T95 G96 F98 S118 C150 A181 N314 Y318
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:3cps, PDBe:3cps, PDBj:3cps
PDBsum3cps
PubMed
UniProtQ5CWT6

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