Structure of PDB 3cop Chain A

Receptor sequence

>3copA (length=476) Species: 562 (Escherichia coli)

MQVLHVCSEMFPLLKTGGLADVIGALPAAQIADGVDARVLLPAFPDIRRG
VTDAQVVSRRDTFAGHITLLFGHYNGVGIYLIDAPHLYDRPGSPYHDTNL
FAYTDNVLRFALLGWVGAEMASGLDPFWRPDVVHAHDWHAGLAPAYLAAR
GRPAKSVFTVHNLAYQGMFYAHHMNDIQLPWSFFNIHGLEFNGQISFLKA
GLYYADHITAVSPTYAREITEPQFAYGMEGLLQQRHREGRLSGVLNGVDE
KIWSPETDLLLASRYTRDTLEDKAENKRQLQIAMGLKVDDKVPLFAVVSR
LTSQKGLDLVLEALPGLLEQGGQLALLGAGDPVLQEGFLAAAAEYPGQVG
VQIGYHEAFSHRIMGGADVILVPSRFAPCGLTQLYGLKYGTLPLVRRTGG
LADTVSDCSLENLADGVASGFVFEDSNAWSLLRAIRRAFVLWSRPSLWRF
VQRQAMAMDFSWQVAAKSYRELYYRL

3D structure

• PDB: 3cop The Crystal Structures of the Open and Catalytically Competent Closed Conformation of Escherichia coli Glycogen Synthase.
• Chain: A
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 2.4.1.21: starch synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GLC	A	Y165 T302 Q304	Y165 T302 Q304
BS02	ADP	A	K15 G17 G18 V298 K305 Y355 H356 L381 T382	K15 G17 G18 V298 K305 Y355 H356 L381 T382
BS03	250	A	L19 Y95 W138 H139 Y165	L19 Y95 W138 H139 Y165

Gene Ontology

Molecular Function

• GO:0004373 alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity
• GO:0009011 alpha-1,4-glucan glucosyltransferase (ADP-glucose donor) activity
• GO:0016757 glycosyltransferase activity

Biological Process

• GO:0005978 glycogen biosynthetic process
• GO:0006974 DNA damage response

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:3cop, PDBe:3cop, PDBj:3cop
• PDBsum: 3cop
• PubMed: 19244233
• UniProt: P0A6U8|GLGA_ECOLI Glycogen synthase (Gene Name=glgA)