Structure of PDB 3cn8 Chain A

Receptor sequence
>3cn8A (length=494) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
SPAKKKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRLQTVTGY
QGRKYDIGASWHHDTLTNPLFLEEAQLSLNDGRTRFVFDDDNFIYIDEER
GRVDHDKELLLEIVDNEMSKFAELEFHQHLGVSDCSFFQLVMKYLLQRRQ
FLTNDQIRYLPQLCRYLELWHGLDWKLLSAKDTYFGHQGRNAFALNYDSV
VQRIAQSFPQNWLKLSCEVKSITREPSKNVTVNCEDGTVYNADYVIITVP
QSVLNLSVQPEKNLRGRIEFQPPLKPVIQDAFDKIHFGALGKVIFEFEEC
CWSNESSKIVTLANSTNEFVEIVRNAENLDELDSMLERETSVTCWSQPLF
FVNLSKSTGVASFMMLMQAPLTNHIESIREDKERLFSFFQPVLNKIMKCL
DSEDVIDGMRANKPVLRNIIVSNWTRDPYSRGAYSACFPGDDPVDMVVAM
SNGQDSRIRFAGEHTIMDGAGCAYGAWESGRREATRISDLLKLE
3D structure
PDB3cn8 Crystal structure of fms1 in complex with spermidine
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H67
Catalytic site (residue number reindexed from 1) H63
Enzyme Commision number 1.5.3.17: non-specific polyamine oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G15 G17 A19 E39 A40 R41 G46 R47 G62 A63 S64 W65 H67 V223 T252 V253 G270 L294 W440 A449 Y450 G478 E479 G487 C488 A489 A492 G11 G13 A15 E35 A36 R37 G42 R43 G58 A59 S60 W61 H63 V219 T248 V249 G266 L290 W424 A433 Y434 G462 E463 G471 C472 A473 A476
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0016491 oxidoreductase activity
GO:0046592 polyamine oxidase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0052897 N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
GO:0052901 spermine oxidase activity
GO:0052903 N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity
Biological Process
GO:0006338 chromatin remodeling
GO:0015940 pantothenate biosynthetic process
GO:0046208 spermine catabolic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:3cn8, PDBe:3cn8, PDBj:3cn8
PDBsum3cn8
PubMed
UniProtP50264|FMS1_YEAST Polyamine oxidase FMS1 (Gene Name=FMS1)

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