Structure of PDB 3cmd Chain A

Receptor sequence
>3cmdA (length=186) Species: 1352 (Enterococcus faecium) [Search protein sequence]
LVPGRHMMITMDDIIREGNPTLREVAKEVSLPLSEEDISLGKEMLEFLKN
SQDPIKAEELHLRGGVGLAAPQLDISKRIIAVHVPSSLSTVMYNPKILSH
SVQDACLGEGEGCLSVDREVPGYVVRHAKITVSYYDMNGEKHKIRLKNYE
SIVVQHEIDHINGVMFYDHINDQNPFALKEGVLVIE
3D structure
PDB3cmd Insight into the antibacterial drug design and architectural mechanism of peptide recognition from the E. faecium peptide deformylase structure.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G60 Q65 C114 L115 H157 E158 H161
Catalytic site (residue number reindexed from 1) G67 Q72 C113 L114 H156 E157 H160
Enzyme Commision number 3.5.1.88: peptide deformylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A C114 H157 H161 C113 H156 H160
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0042586 peptide deformylase activity
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0018206 peptidyl-methionine modification

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3cmd, PDBe:3cmd, PDBj:3cmd
PDBsum3cmd
PubMed18831047
UniProtQ842S4

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