Structure of PDB 3cm7 Chain A

Receptor sequence
>3cm7A (length=101) Species: 9606 (Homo sapiens) [Search protein sequence]
TNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHC
GGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLV
R
3D structure
PDB3cm7 Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C300 C303 H320 C327 C47 C50 H67 C74
BS02 X22 A G306 L307 T308 D309 W310 E314 Q319 W323 Y324 G53 L54 T55 D56 W57 E61 Q66 W70 Y71 BindingDB: IC50=290nM
External links
PDB RCSB:3cm7, PDBe:3cm7, PDBj:3cm7
PDBsum3cm7
PubMed18851976
UniProtP98170|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)

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