Structure of PDB 3cln Chain A

Receptor sequence

>3clnA (length=143) Species: 10117 (Rattus rattus) [Search protein sequence]

TEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINE
VDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAE
LRHVMTNLGEKLTDEEVDEMIREANIDGDGQVNYEEFVQMMTA

3D structure

PDB

3cln Structure of calmodulin refined at 2.2 A resolution.

Chain

Resolution

2.2 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	V35
Catalytic site (residue number reindexed from 1)	V31
Enzyme Commision number	?

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	A	D20 D22 D24 T26 E31	D16 D18 D20 T22 E27
BS02	CA	A	D56 D58 N60 T62 E67	D52 D54 N56 T58 E63
BS03	CA	A	D93 D95 N97 Y99 E104	D89 D91 N93 Y95 E100
BS04	CA	A	N129 D131 D133 Q135 E140	N125 D127 D129 Q131 E136

Gene Ontology

	Molecular Function
GO:0005246	calcium channel regulator activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008179	adenylate cyclase binding
GO:0010856	adenylate cyclase activator activity
GO:0019855	calcium channel inhibitor activity
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0030235	nitric-oxide synthase regulator activity
GO:0031432	titin binding
GO:0031800	type 3 metabotropic glutamate receptor binding
GO:0043539	protein serine/threonine kinase activator activity
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0044325	transmembrane transporter binding
GO:0046872	metal ion binding
GO:0048306	calcium-dependent protein binding
GO:0050998	nitric-oxide synthase binding
GO:0072542	protein phosphatase activator activity

	Biological Process
GO:0000086	G2/M transition of mitotic cell cycle
GO:0001975	response to amphetamine
GO:0002027	regulation of heart rate
GO:0005513	detection of calcium ion
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0016240	autophagosome membrane docking
GO:0032465	regulation of cytokinesis
GO:0035458	cellular response to interferon-beta
GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT
GO:0051592	response to calcium ion
GO:0051649	establishment of localization in cell
GO:0055117	regulation of cardiac muscle contraction
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0071346	cellular response to type II interferon
GO:0090150	establishment of protein localization to membrane
GO:0090151	establishment of protein localization to mitochondrial membrane
GO:0098901	regulation of cardiac muscle cell action potential
GO:0140056	organelle localization by membrane tethering
GO:0140238	presynaptic endocytosis
GO:1900242	regulation of synaptic vesicle endocytosis
GO:1990456	mitochondrion-endoplasmic reticulum membrane tethering
GO:2000300	regulation of synaptic vesicle exocytosis

	Cellular Component
GO:0000922	spindle pole
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005876	spindle microtubule
GO:0008076	voltage-gated potassium channel complex
GO:0030017	sarcomere
GO:0030426	growth cone
GO:0030672	synaptic vesicle membrane
GO:0031514	motile cilium
GO:0031966	mitochondrial membrane
GO:0032991	protein-containing complex
GO:0034704	calcium channel complex
GO:0043209	myelin sheath
GO:0044305	calyx of Held
GO:0097225	sperm midpiece
GO:0098685	Schaffer collateral - CA1 synapse
GO:0099523	presynaptic cytosol
GO:0099524	postsynaptic cytosol
GO:0150034	distal axon
GO:1902494	catalytic complex

External links

PDB	RCSB:3cln, PDBe:3cln, PDBj:3cln
PDBsum	3cln
PubMed	3145979
UniProt	P0DP29\|CALM1_RAT Calmodulin-1 (Gene Name=Calm1)