Structure of PDB 3cld Chain A

Receptor sequence
>3cldA (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
PQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAV
KWAKAIPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQNLLCFAPDLI
INEQRMTLPGMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKD
GLKSQELFDEIRMTYIKELGKAIVKRQNWQRFYQLTKLLDSMHEVVENLL
NYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ
3D structure
PDB3cld X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocorticoid receptor-ligand binding domain.
ChainA
Resolution2.84 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V575 K579 L589 M593 V50 K54 L64 M68
BS02 GW6 A M560 L563 N564 G567 Q570 M601 M604 A605 F623 M639 C643 Y735 C736 T739 M35 L38 N39 G42 Q45 M76 M79 A80 F95 M111 C115 Y202 C203 T206 BindingDB: Ki=0.510000nM,IC50=0.0398nM,EC50=0.400000nM
External links
PDB RCSB:3cld, PDBe:3cld, PDBj:3cld
PDBsum3cld
PubMed18522385
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

[Back to BioLiP]