Structure of PDB 3cl2 Chain A

Receptor sequence
>3cl2A (length=385) Species: 284218 (Influenza A virus (A/Viet Nam/1203/2004(H5N1))) [Search protein sequence]
VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFISCSHLECRTF
FLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSAS
ACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECA
CVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCY
PNAGEITCVCRDSWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGT
GSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTE
TDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPK
ESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI
3D structure
PDB3cl2 Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants.
ChainA
Resolution2.538 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 E277 R292 R371 Y406
Catalytic site (residue number reindexed from 1) D69 E196 R211 R286 Y320
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G39 A E119 D151 W178 S246 R292 Y347 R371 Y406 E37 D69 W97 S165 R211 Y262 R286 Y320 PDBbind-CN: -logKd/Ki=7.59,Ki=25.9nM
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3cl2, PDBe:3cl2, PDBj:3cl2
PDBsum3cl2
PubMed18480754
UniProtQ6DPL2|NRAM_I04A1 Neuraminidase (Gene Name=NA)

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