Structure of PDB 3ckx Chain A

Receptor sequence
>3ckxA (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
PEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEDEIEDIQQEI
TVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQI
ATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTD
TQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSE
LHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKH
KFILRNAKKTSYLTELIDRYKRWKAEQ
3D structure
PDB3ckx Crystal structure of sterile 20-like kinase 3 (MST3, STK24) in complex with staurosporine.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D129 K131 A133 N134 D147 D156 T167
Catalytic site (residue number reindexed from 1) D123 K125 A127 N128 D141 D150 T161
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU A I15 K17 V23 A36 M84 E85 Y86 L87 G90 S91 A133 L136 D147 I11 K13 V19 A32 M78 E79 Y80 L81 G84 S85 A127 L130 D141
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3ckx, PDBe:3ckx, PDBj:3ckx
PDBsum3ckx
PubMed
UniProtQ9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (Gene Name=STK24)

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