Structure of PDB 3cj5 Chain A

Receptor sequence
>3cj5A (length=562) Species: 31647 (Hepatitis C virus subtype 1b) [Search protein sequence]
HHMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSAGLRQ
KKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKS
KFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEVFCVQP
EGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRV
EFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQ
AIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASA
ACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMTRYSAPPG
DPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETAR
HTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGAC
YSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWR
HRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASRLDLSGWF
VAGYSGGDIYHS
3D structure
PDB3cj5 Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors.
ChainA
Resolution1.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SX6 A R422 M423 H475 S476 L497 R498 R501 W528 R421 M422 H474 S475 L496 R497 R500 W527 MOAD: Kd=0.46uM
PDBbind-CN: -logKd/Ki=6.34,Kd=0.46uM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:3cj5, PDBe:3cj5, PDBj:3cj5
PDBsum3cj5
PubMed18400495
UniProtP26663|POLG_HCVBK Genome polyprotein

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