Structure of PDB 3chf Chain A

Receptor sequence

>3chfA (length=395)

ASSGYRSVVYFVNWAIYGRNHNPQDLPVERLTHVLYAFANVRPETGEVYM
TDSWADIEKHYPGDSWSDTGNNVYGCIKQLYLLKKQNRNLKVLLSIGGWT
YSPNFAPAASTDAGRKNFAKTAVKLLQDLGFDGLDIDWEYPENDQQANDF
VLLLKEVRTALDSYSAANAGGQHFLLTVASPAGPDKIKVLHLKDMDQQLD
FWNLMAYDYAGSFSSLSGHQANVYNDTSNPLSTPFNTQTALDLYRAGGVP
ANKIVLGMPLYGRSFANTDGPGKPYNGVGQGSWENGVWDYKALPQAGATE
HVLPDIMASYSYDATNKFLISYDNPQVANLKSGYIKSLGLGGAMWWDSSS
DKTGSDSLITTVVNALGGTGVFEQSQNELDYPVSQYDNLRNGMQT

3D structure

• PDB: 3chf Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin.
• Chain: A
• Resolution: 1.95 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D173 D175 E177 Y245
• Catalytic site (residue number reindexed from 1): D135 D137 E139 Y207
• Enzyme Commision number: 3.2.1.14: chitinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	Y48 W137 D175 E177 M243 Y245 D246 F251 R301 E322 W384	Y10 W99 D137 E139 M205 Y207 D208 F213 R263 E284 W346

Gene Ontology

Molecular Function

• GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
• GO:0008061 chitin binding

Biological Process

• GO:0005975 carbohydrate metabolic process

External links

• PDB: RCSB:3chf, PDBe:3chf, PDBj:3chf
• PDBsum: 3chf
• PubMed: 18355729
• UniProt: Q873X9|CHIB1_ASPFM Endochitinase B1 (Gene Name=chiB1)