Structure of PDB 3ce0 Chain A

Receptor sequence
>3ce0A (length=352) Species: 9606 (Homo sapiens) [Search protein sequence]
KRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIA
RGFEALEALEEALKDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQ
AKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLD
SGAPEYKVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSKLGNRK
LLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENSKSAGYVIGMK
CGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPT
QDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLE
VH
3D structure
PDB3ce0 Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S422 Y425 E514
Catalytic site (residue number reindexed from 1) S242 Y245 E334
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P34 A D284 H384 G385 Y414 F415 S422 Y425 E514 D104 H204 G205 Y234 F235 S242 Y245 E334 PDBbind-CN: -logKd/Ki=6.15,Kd=0.7uM
BindingDB: IC50=1430nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:3ce0, PDBe:3ce0, PDBj:3ce0
PDBsum3ce0
PubMed19354255
UniProtQ9Y6F1|PARP3_HUMAN Protein mono-ADP-ribosyltransferase PARP3 (Gene Name=PARP3)

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