Structure of PDB 3cd3 Chain A

Receptor sequence

>3cd3A (length=353) Species: 9606 (Homo sapiens)

SMIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQEYVLSVPRH
FIINLYRLFPSIPLLIDHLLSTQQPLSGVVLHRAVPKDKWVLNHEDLVLG
EQIGRGNFGEVFSGRLRADNTLVAVKSCRPDLKAKFLQEARILKQYSHPN
IVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAA
AGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGG
LRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQ
TREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR
KRH

3D structure

• PDB: 3cd3 Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
• Chain: A
• Resolution: 1.98 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D683 A685 R687 N688 D701 G718
• Catalytic site (residue number reindexed from 1): D215 A217 R219 N220 D233 G250
• Enzyme Commision number: 2.7.10.2: non-specific protein-tyrosine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	D683 R687 L719 R720 Q721 V722 P723 V724 N766 R770	D215 R219 L251 R252 Q253 V254 P255 V256 N298 R302
BS02	STU	A	I567 R569 A588 E607 E637 L638 V639 G642 D643 R687 L690 S700 D701	I103 R105 A124 E139 E169 L170 V171 G174 D175 R219 L222 S232 D233
BS03	STU	A	D583 T585 R621 L622 I623	D119 T121 R153 L154 I155
BS04	STU	A	H456 E559 R581	H11 E95 R117

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:3cd3, PDBe:3cd3, PDBj:3cd3
• PDBsum: 3cd3
• PubMed: 18775312
• UniProt: P07332|FES_HUMAN Tyrosine-protein kinase Fes/Fps (Gene Name=FES)