Structure of PDB 3ccn Chain A

Receptor sequence
>3ccnA (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
LSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLKIHCAVK
SLNREVSQFLTEGIIMKDFSHPNVLSLLGICLPLVVLPYMKHGDLRNFIR
NETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKV
ADFGLARDMYDKEYYSVHKTGAKLPVKWMALESLQTQKFTTKSDVWSFGV
LLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWH
PKAEMRPSFSELVSRISAIFSTFIG
3D structure
PDB3ccn Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1204 A1206 R1208 N1209 D1222 A1243
Catalytic site (residue number reindexed from 1) D134 A136 R138 N139 D152 A172
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LKG A A1108 L1157 M1160 D1164 R1208 M1211 A1221 D1222 Y1230 A48 L87 M90 D94 R138 M141 A151 D152 Y160 MOAD: ic50=120nM
PDBbind-CN: -logKd/Ki=6.92,IC50=120nM
BindingDB: IC50=120nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3ccn, PDBe:3ccn, PDBj:3ccn
PDBsum3ccn
PubMed18426196
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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