Structure of PDB 3cbp Chain A

Receptor sequence
>3cbpA (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
GVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIE
GKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERV
YVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNT
LSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPI
KCIRTLRAVEADEELTVAYGYDHEAPEWYQVELKAFQAT
3D structure
PDB3cbp Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase.
ChainA
Resolution1.42 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y245 H293 H297 Y305 Y335
Catalytic site (residue number reindexed from 1) Y129 H177 H181 Y189 Y219
Enzyme Commision number 2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V255 D256 R258 N263 T266 L267 S268 Y305 Y335 Y337 E348 V139 D140 R142 N147 T150 L151 S152 Y189 Y219 Y221 E224
BS02 SFG A A226 E228 G264 N265 H293 K294 N296 H297 Y335 W352 E356 A110 E112 G148 N149 H177 K178 N180 H181 Y219 W228 E232 PDBbind-CN: -logKd/Ki=5.60,IC50=2.5uM
BindingDB: IC50=2500nM
Gene Ontology
Molecular Function
GO:0016279 protein-lysine N-methyltransferase activity
GO:0140945 histone H3K4 monomethyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:3cbp, PDBe:3cbp, PDBj:3cbp
PDBsum3cbp
PubMed18471979
UniProtQ8WTS6|SETD7_HUMAN Histone-lysine N-methyltransferase SETD7 (Gene Name=SETD7)

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