Structure of PDB 3c9e Chain A

Receptor sequence
>3c9eA (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
APDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSP
QNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNP
TGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVY
YDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNK
NNACGIANLASFPKM
3D structure
PDB3c9e The crystal and molecular structures of a cathepsin K:chondroitin sulfate complex.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H162 N182
Catalytic site (residue number reindexed from 1) Q19 C25 H162 N182
Enzyme Commision number 3.4.22.38: cathepsin K.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BDP A N190 K191 N190 K191
BS02 ASG A R8 N190 L195 R8 N190 L195
BS03 BDP A K9 Q172 K9 Q172
BS04 ASG A G170 I171 G170 I171
BS05 ASG A V5 D6 K10 V5 D6 K10
BS06 CA A E59 N70 Q73 E59 N70 Q73
BS07 E64 A Q19 G23 C25 E59 N60 G65 G66 Y67 L160 H162 Q19 G23 C25 E59 N60 G65 G66 Y67 L160 H162 PDBbind-CN: -logKd/Ki=8.00,Kd=10nM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3c9e, PDBe:3c9e, PDBj:3c9e
PDBsum3c9e
PubMed18692071
UniProtP43235|CATK_HUMAN Cathepsin K (Gene Name=CTSK)

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