Structure of PDB 3c8e Chain A

Receptor sequence
>3c8eA (length=284) Species: 562 (Escherichia coli) [Search protein sequence]
TYQPAKVWTWDKSAGGAFANINRPVSGPTHEKTLPVGKHPLQLYSLGTPN
GQKVTIMLEELLALGVTGAEYDAWLIRIGDGDQFSSGFVEVNPNSKIPAL
RDHTHNPPIRVFESGSILLYLAEKFGYFLPQDLAKRTETMNWLFWLQGAA
PFLGGGFGHFYHYAPVKIEYAINRFTMEAKRLLDVLDKQLAQHKFVAGDE
YTIADMAIWPWFGNVVLGGVYDAAEFLDAGSYKHVQRWAKEVGERPAVKR
GRIVNRTNGPLNEQLHERHDASDFETNTEDKRQG
3D structure
PDB3c8e Structure and Function of YghU, a Nu-Class Glutathione Transferase Related to YfcG from Escherichia coli.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.11.1.-
1.8.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GSH A T52 N54 I82 Q87 K100 I101 E117 S118 T48 N50 I78 Q83 K96 I97 E113 S114 MOAD: Kd=0.07mM
PDBbind-CN: -logKd/Ki=4.15,Kd=0.07mM
BS02 GSH A F22 N26 T52 N54 P155 G158 W215 F18 N22 T48 N50 P151 G154 W211 MOAD: Kd=0.07mM
PDBbind-CN: -logKd/Ki=4.15,Kd=0.07mM
Gene Ontology
Molecular Function
GO:0004601 peroxidase activity
GO:0015036 disulfide oxidoreductase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0098869 cellular oxidant detoxification

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Molecular Function
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Biological Process
External links
PDB RCSB:3c8e, PDBe:3c8e, PDBj:3c8e
PDBsum3c8e
PubMed21222452
UniProtQ46845|YGHU_ECOLI Disulfide-bond oxidoreductase YghU (Gene Name=yghU)

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