Structure of PDB 3c84 Chain A

Receptor sequence
>3c84A (length=210) Species: 6500 (Aplysia californica) [Search protein sequence]
DKLHSQANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKADSST
NEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTR
PVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSW
VYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYID
VNLVVKFRER
3D structure
PDB3c84 Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore.
ChainA
Resolution1.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TH4 A W147 Y188 C190 Y195 W150 Y191 C193 Y198 MOAD: Kd=14nM
PDBbind-CN: -logKd/Ki=7.85,Kd=14nM
BindingDB: Ki=3.9nM
BS02 TH4 A Y55 M116 I118 Y58 M119 I121 MOAD: Kd=14nM
PDBbind-CN: -logKd/Ki=7.85,Kd=14nM
BindingDB: Ki=3.9nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:3c84, PDBe:3c84, PDBj:3c84
PDBsum3c84
PubMed18477694
UniProtQ8WSF8

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