Structure of PDB 3c6m Chain A

Receptor sequence
>3c6mA (length=336) Species: 9606 (Homo sapiens) [Search protein sequence]
SRHSTLDFMLGDGETILKGLQSIFQEQGMAESVHTWQDHGYLATYTNKNG
SFANLRIYPHGLVLLDLQSYDSILNKVEERMKELSVKRLPPIVRGGAIDR
YWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAE
SDLAYTRAIMGSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEID
QMVIDGCKKYMRKTCGDVLDNLKGDCYQVLIEDCIPVLKRYAKEGREFDY
VINDLTAVPISTTWEFLRLILDLSMKVLKQDGKYFTQGNCVNLTEALSLY
EEQLGRLYCPVEFSKEIVCVPSYLELWVFYTVWKKA
3D structure
PDB3c6m Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism.
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.22: spermine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SPM A P125 Y134 D167 V168 N169 Y177 D276 L277 Y351 E353 W355 P103 Y112 D145 V146 N147 Y155 D254 L255 Y323 E325 W327
BS02 MTA A Q148 L164 N169 G198 G199 D201 V219 E220 I221 D255 C256 D276 L277 T278 I282 Q126 L142 N147 G176 G177 D179 V197 E198 I199 D233 C234 D254 L255 T256 I260 MOAD: Ki=0.3uM
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0016768 spermine synthase activity
Biological Process
GO:0006555 methionine metabolic process
GO:0006595 polyamine metabolic process
GO:0006596 polyamine biosynthetic process
GO:0006597 spermine biosynthetic process
GO:0008215 spermine metabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3c6m, PDBe:3c6m, PDBj:3c6m
PDBsum3c6m
PubMed18367445
UniProtP52788|SPSY_HUMAN Spermine synthase (Gene Name=SMS)

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