Structure of PDB 3c4m Chain A

Receptor sequence

>3c4mA (length=469) Species: 9606,83333

AKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQ
VAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRY
NGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMF
NLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLI
KNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPT
FKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPL
GAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVIN
AASGRQTVDEALKDAQTNAAAEFDDVMTKEEQIFLLHRAQAQCEKRLKEV
RPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWE
LVPGHNRTWANYSECVKFL

3D structure

• PDB: 3c4m Molecular recognition of parathyroid hormone by its G protein-coupled receptor.
• Chain: A
• Resolution: 1.95 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	D29 D30 M32 Q37 I38 L41 E111 W112 D113 H114 I115 Y136 D137 R146 R162 T163 V171 L174	D374 D375 M377 Q382 I383 L386 E406 W407 D408 H409 I410 Y431 D432 R441 R457 T458 V466 L469
BS02	GLC	A	D-330 K-329 E-233 Y-189 W-114	D15 K16 E112 Y156 W231
BS03	GLC	A	W-282 D-279 R-278 E-191 P-190 Y-189 W-4	W63 D66 R67 E154 P155 Y156 W341

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0015144 carbohydrate transmembrane transporter activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0008643 carbohydrate transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:3c4m, PDBe:3c4m, PDBj:3c4m
• PDBsum: 3c4m
• PubMed: 18375760
• UniProt: P0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
  Q03431|PTH1R_HUMAN Parathyroid hormone/parathyroid hormone-related peptide receptor (Gene Name=PTH1R)