Structure of PDB 3c4c Chain A

Receptor sequence
>3c4cA (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQA
FKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETK
FEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGS
GSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ
IIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEI
EELARELS
3D structure
PDB3c4c Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
ChainA
Resolution2.57 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D576 K578 N580 N581 D594 S616
Catalytic site (residue number reindexed from 1) D129 K131 N133 N134 D147 S152
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 324 A A481 K483 L514 I527 T529 Q530 W531 C532 F583 D594 F595 A34 K36 L67 I80 T82 Q83 W84 C85 F136 D147 F148 PDBbind-CN: -logKd/Ki=6.80,IC50=160nM
BindingDB: IC50=13nM,Ki=2.6nM,Kd=100nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3c4c, PDBe:3c4c, PDBj:3c4c
PDBsum3c4c
PubMed18287029
UniProtP15056|BRAF_HUMAN Serine/threonine-protein kinase B-raf (Gene Name=BRAF)

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